Overview
NAD+ is an endogenous coenzyme central to redox metabolism, sirtuin activity and DNA-repair signaling — a molecule under intensive investigation in longevity and mitochondrial research.
Mechanism of action
Serves as substrate for sirtuins, PARPs and CD38. Direct supplementation is investigated for its ability to raise intracellular NAD+ pools and influence downstream mitochondrial biogenesis pathways.
Research summary
Preclinical studies explore mitochondrial function, DNA repair signaling and age-related decline.
Research applications
- Longevity and healthspan research
- Mitochondrial and metabolic studies
- Cognitive and neuroprotective investigation
Typical research dosing
| Period | Dose | Units (U-100) |
|---|---|---|
| Research protocol | 50–300 mg | — |
Reconstitution & storage
Reconstitute with 3 mL bacteriostatic water for 500 mg vial.
Safety
Research use only.
References
- Rajman L. et al. Cell Metabolism 2018;27:529-547
For research use only. Not for human or veterinary consumption. Not FDA-approved for the treatment or prevention of any disease.